Sudoku 12x12 - Medium

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This Sudoku variant consists of a 12 x 12 grid made up of 4 x 3 subgrids (called “regions”). Some cells already contain numbers. The goal is to fill the empty cells with one number each, so that each column, row, and region contains the numbers 1 through 12 exactly once. Each number in the solution thus occurs only once in each of the three “directions”, hence the “single numbers” implied by the name of the puzzle.