Sudoku 8x8 - Medium

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This Sudoku variant consists of a 8x8 grid made up of 4x2 subgrids (called “regions”). Some cells already contain numbers. The goal is to fill the empty cells with one number each, so that each column, row, and region contains the numbers 1 through 8 exactly once. Each number in the solution thus occurs only once in each of the three “directions”, hence the “single numbers” implied by the name of the puzzle.